Moriah R. Beck
Moriah BEck


Title: Assistant Professor

Education: Ph.D., Washington University in St. Louis, 2007

Research Area: Biochemistry

Phone: 316-978-5476

Lab: 316-978-7384

Fax: 316-978-3431

E-mail: moriah.beck@wichita.edu

Beck Group Homepage




Principal Research Interests

My research seeks to understand transformations of the actin cytoskeleton that occur in both normal and invasive motility.  Of particular interest are the strategies employed by actin binding proteins to promote invasive cell motility associated with metastatic cancer progression.  The majority of my laboratory’s efforts are directed at defining the molecular mechanisms involving regulation of F-actin structures by palladin.  We use a multi-disciplinary approach that combines biochemistry, mutagenesis, structural biology, and single molecule microscopy to study these problems from the molecular to cellular level. Our work includes defining the structure and function of individual purified proteins and reconstituting more complex multi-component activities and interactions.  The Beck Lab also thrives to understand protein function in the context of living cells through multiple collaborations with cell biologists.


Representative Publications

  1. Gurung, R., Yadav, R., Brungardt, J.G., Orlova, A., Egelman, E.H., Beck, M.R. (2015) Actin polymerization is stimulated by actin crosslinking protein palladin. Biochem J. pii: BJ20151050. [Epub ahead of print] PMID: 26607837
  2. Elsarraj, H.S., Hong, Y., Valdez, K.E., Michaels, W., Hook, M., Smith, W.P., Chien, J., Herschkowitz, J.I., Troester, M.A., Beck, M.R., Inciardi, M., Gatewood, J., May, L., Cusick, T., McGinness, M., Ricci, L., Fan, F., Tawfik, O., Marks, J.R., Knapp, J.R., Yeh, H.W., Thomas, P., Carrasco, D.R., Fields, T.A., Godwin, A.K., Behbod, F. (2015) Expression profiling of in vivo ductal carcinoma in situ progression models identified B cell lymphoma-9 as a molecular driver of breast cancer invasion. Breast Cancer Res. 17: 128-. PMID:  26384318
  3. Thompson, P.M., Beck, M.R., Campbell, S.L. (2015) Protein-Protein Interaction Analysis by Nuclear Magnetic Resonance Spectroscopy. Methods in Molecular Biology 1278: 267-279.  PMID:  25859955
  4. Vattepu, R., Yadav, R., Beck, M.R. (2015) Actin-induced dimerization of palladin promotes actin-bundling. Protein Sci. 24: 70-80. PMID: 25307943
  5. Beck, M.R., Dixon, R.D., Goicoechea, S.M., Murphy, G.S., Brungardt, J.G., Beam, M.T., Srinath, P., Mohiuddin,J., Otey, C.A. and Campbell, S.L. (2013) Structure and function of palladin’s actin binding domain. J Mol Biol. 425: 3325-3337. PMID:  23806659
  6. Beck, MR, Otey, CA, Campbell, SL (2011) Structural characterization of the interactions between palladin and alpha-actinin. J Mol Biol. 413(3):  712-725. PMID:  21925511